Thyroid hormone receptor localization in target tissues
نویسندگان
چکیده
منابع مشابه
Thyroid Stimulating Hormone Receptor
Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial role in tumor growth, which is initiated by sev...
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Review on THRB, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
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Thyroid hormone (TH) actions are mediated by nuclear receptors (TRs alpha and beta) that bind triiodothyronine (T(3), 3,5,3'-triiodo-l-thyronine) with high affinity, and its precursor thyroxine (T(4), 3,5,3',5'-tetraiodo-l-thyronine) with lower affinity. T(4) contains a bulky 5' iodine group absent from T(3). Because T(3) is buried in the core of the ligand binding domain (LBD), we have predict...
متن کاملPartial target organ resistance to thyroid hormone.
An 8-year old boy with a small goiter, normal basal metabolic rate (BMR), and elevated serum thyroid hormone levels (thyroxine [T(4)] 19.5 mug per 100 ml, free T(4) 4 ng per 100 ml, triiodothyronine [T(3)] 505 ng per 100 ml) was studied. He had measurable serum thyroid-stimulating hormone (TSH) levels (average 5.5 muU per ml), and the thyroxine-binding proteins, hearing, and epiphyseal structur...
متن کاملThyroid Hormone Receptor Coregulators in Metabolic Regulation
It has been known for a long time that thyroid hormone regulates metabolism. Thyroid hormone action is primarily mediated by Thyroid Hormone Receptors (TRs). The transcriptional regulation by TRs is modulated by coregulators including coactivators and corepressors. Emerging evidence suggested that coregulators are critical for metabolic regulation mediated by TR. This review describes recent in...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2018
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-17-0708